Celtics vs. 76ers Prediction, Odds, Picks – Oct. 22

The Boston Celtics square off against the Philadelphia 76ers on October 22, 2025 in the opening game of the 2025-26 season for both teams. The Celtics play the 76ers in a game that Boston is currently a slim favorite by 2 points. The over/under is 226.5 points for the game.

Here’s everything you need to know about the Celtics-76ers game, from the point spread, moneyline, total Over/Under and expert picks, as well as TV channel and streaming information.

Celtics vs. 76ers Game Information, TV Channel & Odds

• When: Wednesday, October 22, 2025 at 7:30 p.m. ET
• Where: TD Garden in Boston, Massachusetts
• TV: NBCS-BOS and NBCS-PH
• Live Boxscore: FOX Sports

Celtics vs. 76ers Prediction

ATS Pick: Celtics (- 2)
O/U Pick: Under (226.5)
Score Prediction: Celtics 122 – 76ers 101

Celtics vs. 76ers Betting Insights

• The Celtics and their opponents went over 226.5 combined points in 36 of 82 games last season.
• The 76ers combined with their opponent to score more than 226.5 points in 37 of 82 games last season.
• The teams combined to score 225.9 points per contest last season, 0.6 fewer points than this game’s point total.
• Opponents of these teams combined to average 223 points per game last year, 3.5 fewer points than this contest’s total.
• The Celtics had an average total of 226.3 in their matchups last season, 0.2 fewer points than this game’s over/under.
• The average over/under for 76ers contests last year was 222.4, 4.1 fewer points than this game’s point total.

Celtics Recent Trends

• Boston covered 39 times in 82 matchups with a spread last season.
• Boston was favored by 2 points or more 75 times last season, and covered the spread in 36 of those games.
• Last season, 37 Boston games banger the over.
• Last year, the Celtics scored 116.3 points per game, only 0.5 more points than the 115.8 the 76ers allowed.
• Boston went 30-16 against the spread and 41-5 overall last season when scoring more than 115.8 points.
• The Celtics made 46.2% of their shots from the field last season, which was 2.6 percentage points lower than the 76ers allowed to their opponents (48.8%).
• Against the spread last year, the Celtics played worse when played at home, covering 18 times in 41 home games, and 21 times in 41 road games.
• Boston eclipsed the total more consistently at home last season, hitting the over in 21 of 41 home matchups (51.2%). In road games, it banger the over in 16 of 41 games (39%).
• The Celtics won a lower percentage of their games as a moneyline favorite at home last year, going 27-13 (.675). On the road as a moneyline favorite, they sported a record of 32-6 (.842).

Celtics Recent Stats

Celtics Leaders

• Jayson Tatum posted 26.8 points, 8.7 rebounds and 6.0 assists last year. He also drained 45.2% of his shots from the field and 34.3% from beyond the arc, with 3.5 triples per contest (fourth in NBA).
• Per game, Derrick White posted 16.4 points, 4.5 rebounds and 4.8 assists. He also averaged 0.9 steals and 1.1 blocks.
• Jaylen Brown posted 22.2 points, 5.8 rebounds and 4.5 assists. He sank 46.3% of his shots from the floor and 32.4% from 3-point range, with 1.8 triples per game.
• Anfernee Simons collected 19.3 points, 2.7 rebounds and 4.8 assists per contest, plus 0.9 steals and 0.1 blocks.
• Payton Pritchard collected 14.3 points, 3.8 rebounds and 3.5 assists. He sank 47.2% of his shots from the floor and 40.7% from 3-point range, with 3.2 treys per game (10th in league).

Celtics Player Props

76ers Recent Trends

• The 76ers covered 29 times in 82 chances against the spread last season.
• Philadelphia went 21-28 as an underdog of 2 points or greater last year.
• A total of 47 of the 76ers’ games last year banger the over.
• The 76ers’ 109.6 points per game last year were just 2.4 more points than the 107.2 the Celtics gave up.
• Philadelphia went 22-23 against the spread and 22-23 overall when it scored more than 107.2 points last season.
• The 76ers shot at a 45.4% clip from the field last season, 0.4 percentage points higher than the 45.0% shooting opponents of the Celtics averaged.
• Last season, the 76ers were 12-29-0 at home against the spread (.293 winning percentage). Away, they were 17-24-0 ATS (.415).
• In 2024-25, a lower percentage of Philadelphia’s games finished above the over/under at home (51.2%, 21 of 41) than on the road (63.4%, 26 of 41).
• The 76ers’ winning percentage at home when moneyline favorites was .412 (7-10) last year, and on the road it was .583 (7-5).

76ers Recent Stats

76ers Leaders

• Tyrese Maxey put up 26.3 points per game last season to go with 6.1 assists.
• Kelly Oubre Jr. averaged 6.1 boards per game in addition to his 15.1 PPG average.
• Quentin Grimes banger an average of 2.2 shots per game from beyond the arc a season ago.
• Oubre and Adem Bona were defensive standouts last season, with Oubre averaging 1.5 steals per game and Bona collecting 1.2 blocks per contest.

76ers Player Props

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.