LOUISVILLE, Ky. — Isaac Brown ran for a career-high 205 yards and a touchdown to help No. 19 Louisville beat Boston College 38-24 on Saturday night.
The Cardinals (6-1, 3-1 Atlantic Coast Conference) had 317 yards on the ground. Brown had 151 on just five carries in the first half.
Brown’s fumble on the first play of the second half led to Grayson James’ 23-yard touchdown pass to Kaelan Chudzinksi that cut the Cardinals’ lead to 21-17.
Miller Moss connected with Caullin Lacy on a 22-yard touchdown pass with 7:34 left to make it 28-17. That score was set up by Antonio Watts’ fumble recovery at the Boston College 27.
Moss completed 15 of 27 passes for 187 yards. He ran for a pair of touchdowns in the first half to go along with his passing score.
The Eagles (1-7, 0-5) were down just 31-24 when they chose to punt near midfield with three minutes left. Keyjuan Brown scored on a 67-yard run with 1:49 remaining for the final touchdown.
Grayson James threw for 244 yards with three touchdowns and two interceptions for the Eagles.

Louisville quarterback Miller Moss (7) hands the ball off to running back Keyjuan Brown (22) during the first half of an NCAA college football game against Boston College in Louisville, Ky., Saturday, Oct. 25, 2025. Credit: AP/Timothy D. Easley
Key takeaways
Boston College: The Eagles came to Louisville with a solid plan to keep the ball away from the Cardinals, and they held the ball for nearly 24 minutes in the first half. Unfortunately, the Cardinals still had enough time to make the big plays they needed.
Louisville: The win was by no means pretty, but it was also the first time the Cardinals, under coach Jeff Brohm, won the next game after upsetting a ranked team. It keeps them in the running for the ACC Championship Game.
Up next
Boston College: Hosts No. 12 Notre Dame on Saturday.
Louisville: At Virginia Tech on Saturday.

Boston College defensive back Omar Thornton, center, grabs the legs of Louisville running back Keyjuan Brown (22) during the second half of an NCAA college football game in Louisville, Ky., Saturday, Oct. 25, 2025. Credit: AP/Timothy D. Easley
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